Picking up the Pieces of Parkin

• 1 Comment

17 Jan 2002

described in the Farrer paper (Farrer et al., 2001) is a partially active mutant as described in our Nature

“Network Epicenters” in Healthy Connectome Predict Dementia

• 3 Comments

16 Apr 2012

June 2012. Preview by Warren et al., 2012 Raj et al., 2012 Zhou et al., 2012 Read a series of questions

Reducing the Risk of Alzheimer Disease

23 Dec 2005

deposition in APP mice, a result observed in three separate laboratories (see Patel et al., 2005 and Wang et

Clioquinol Trial Postmortem: Does Blocking Metal-Aβ Interactions Work?

15 Jan 2004

Indirect evidence is there. APP translation is regulated by iron (Rogers et al., 2002). Alexei Koudinov

Ceramide and Cholesterol: Possible Connections Between Normal Aging of the Brain and Alzheimer’s Disease

15 Oct 2005

(see Constantini et al., 2005) where we show that ceramide levels increase during aging in the brain of

Novel Substrates for BACE1 Beg the Question: What's the Biological Function of β-Secretase?

17 Dec 2003

See Harrison et al., 2003.] Stefan Lichtenthaler Gabrielle, this brings us to the question of

Resolving Controversies on the Path to AD Therapeutics

• 3 Comments

06 Oct 2011

pharma picks them up for human translation (Prinz et al., 2011). Hyped coverage of such publications can

Can We (Should We?) Develop “Smart Drugs” to Stave Off Age-Related Memory Loss?

• 3 Comments

13 Mar 2009

al., 2002; Grön et al., 2005; Chuah and Chee, 2008; FitzGerald et al., 2008). The Alzforum set out to

Vascular Factors in Alzheimer's Disease

21 Apr 2004

but not by apoptosis (we discussed this in Science/Nature several years ago, see Perry et al 1998 and

Calcium Signaling Deficit in the Origin of Alzheimer's Disease

• 8 Comments

07 Sep 2001

1998 May 11;3:a27-31. Abstract. 3. Chen M. The Alzheimer's plaques, tangles and memory deficits

Are Neurons Just Too Laissez-Faire about Repair?

• 1 Comment

24 Jul 2003

do not efficiently repair the bulk of their genome (see, for example, Gobbel et al., 1998). Neurons

The Pathogen Hypothesis—Challenging the Primacy of Genetics in Late-Onset Alzheimer Disease.

• 5 Comments

22 Jan 2006

allele (Corder et al., 1998)! Objection: If pathogens cause AD, why don't we see AD brains full of

LOAD and eFAD—Different Diseases, Different Hypotheses?

05 Mar 2009

flow. (Editor’s note: see recent paper about connectivity data in young ApoE4 data: Filippini et al.,

From Here to There: AβPP as an Axonal Transport Receptor—How Could This Explain Neurodegeneration in AD?

15 Jul 2002

Ashford, Soultanian, et al., 1999. We did not examine axons. However, this discussion seems to be focusing

Caloric Restriction: Eat Less, Live Longer!

• 4 Comments

31 Mar 2005

a model of amyotrophic lateral sclerosis (ALS). It is also important to consider that dietary restriction